Basophils as key regulators of allergic inflammation and Th2-type immunity

Gibbs, Bernhard F (2008) Basophils as key regulators of allergic inflammation and Th2-type immunity. World Allergy Organization Journal, 1 (7). pp. 123-128. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1097/WOX.0b013e31817a76fb

Abstract

Basophils have long been suspected as playing more than a bystander role in initiating and maintaining allergic disorders, despite their relatively low numbers compared with other effector cells, such as mast cells and eosinophils. In vitro studies clearly demonstrated their propensity to generate proallergic cytokines, such as interleukin 4 and interleukin 13, as well as histamine and leukotrienes after simulation with allergens and innate IgE-dependent triggers. However, only very recently have mouse basophils been identified as key regulators of allergy in vivo, including orchestrating Th2 immunity to protease allergens in the induction phase. This review highlights these exciting advances that go far in unraveling our understanding of basophil function in the orchestration of allergic inflammation.

Item Type: Article
Additional information: Review article.
Uncontrolled keywords: basophils; mast cells; Th2 immunity; allergy
Subjects: R Medicine
Q Science > QR Microbiology > QR180 Immunology
Divisions: Faculties > Science Technology and Medical Studies > Medway School of Pharmacy
Depositing User: Bernhard F. Gibbs
Date Deposited: 29 Jun 2011 12:13
Last Modified: 20 May 2014 15:06
Resource URI: http://kar.kent.ac.uk/id/eprint/4788 (The current URI for this page, for reference purposes)
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