Skip to main content

Gold nanoparticles downregulate interleukin-1?-induced pro-inflammatory responses

Sumbayev, Vadim V., Yasinska, Inna M, Garcia, Cesar Pascual, Gilliland, Douglas, Lall, Gurprit S., Gibbs, Bernhard F., Bonsall, David R, Varani, Luca, Rossi, François, Calzolai, Luigi and others. (2013) Gold nanoparticles downregulate interleukin-1?-induced pro-inflammatory responses. Small, 9 (3). pp. 472-477. ISSN 1613-6810. E-ISSN 1613-6829. (doi:10.1002/smll.201201528) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:44723)

PDF
Language: English

Restricted to Repository staff only
[thumbnail of 201201528_ftp.pdf]
Official URL:
http://dx.doi.org/10.1002/smll.201201528

Abstract

Interleukin 1 beta (IL-1?)-dependent inflammatory disorders, such as rheumatoid arthritis and psoriasis, pose a serious medical burden worldwide, where patients face a lifetime of illness and treatment. Organogold compounds have been used since the 1930s to treat rheumatic and other IL-1?-dependent diseases and, though their mechanisms of action are still unclear, there is evidence that gold interferes with the transmission of inflammatory signalling. Here we show for the first time that citrate-stabilized gold nanoparticles, in a size dependent manner, specifically downregulate cellular responses induced by IL-1? both in vitro and in vivo. Our results indicate that the anti-inflammatory activity of gold nanoparticles is associated with an extracellular interaction with IL-1?, thus opening potentially novel options for further therapeutic applications.

Item Type: Article
DOI/Identification number: 10.1002/smll.201201528
Subjects: R Medicine
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Gurprit Lall
Date Deposited: 17 Nov 2014 15:26 UTC
Last Modified: 16 Nov 2021 10:17 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/44723 (The current URI for this page, for reference purposes)

University of Kent Author Information

Sumbayev, Vadim V..

Creator's ORCID: https://orcid.org/0000-0002-9404-5626
CReDIT Contributor Roles:

Lall, Gurprit S..

Creator's ORCID: https://orcid.org/0000-0003-3725-4795
CReDIT Contributor Roles:

Gibbs, Bernhard F..

Creator's ORCID:
CReDIT Contributor Roles:
  • Depositors only (login required):

Total unique views for this document in KAR since July 2020. For more details click on the image.