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Correlation of cell surface marker expression with African swine fever virus infection

Lithgow, Pamela E, Takamatsu, Haru, Werling, Dirk, Dixon, Linda, Chapman, Dave (2014) Correlation of cell surface marker expression with African swine fever virus infection. Veterinary microbiology, 168 (2-4). pp. 413-419. ISSN 1873-2542. (doi:10.1016/j.vetmic.2013.12.001) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:43552)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1016/j.vetmic.2013.12.001

Abstract

The expression of surface markers on African swine fever virus (ASFV) infected cells was evaluated to assess their involvement in infection. Previous findings indicated CD163 expression was correlated with ASFV susceptibility. However, in this study the expression of porcine CD163 on cell lines did not increase the infection rate of these cells indicating other factors are likely to be important in determining susceptibility to infection. On adherent porcine bone marrow (pBM) cells the expression of CD45 was strongly correlated with infection. CD163 and CD203a expression correlated at intermediate levels with infection, indicating cells expressing these markers could become infected but were not preferentially infected by the virus. Most of the cells expressing MHCII were infected, indicating that they may be preferentially infected although expression of MHCII was not essential for infection and a large percentage of the infected cells were MHCII negative. CD16 showed a marked decrease in expression following infection and significantly lower levels of infected cells were shown to express CD16. Altogether these results suggest CD163 may be involved in ASFV infection but it may not be essential; the results also highlight the importance of other cell markers which requiring further investigation.

Item Type: Article
DOI/Identification number: 10.1016/j.vetmic.2013.12.001
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: P.E. Lithgow
Date Deposited: 21 Oct 2014 13:12 UTC
Last Modified: 17 Aug 2022 10:57 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/43552 (The current URI for this page, for reference purposes)

University of Kent Author Information

Lithgow, Pamela E.

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