Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers

Srinivasan, Radhika and Gillett, Cheryl and Barnes, Diana M and Gullick, William J. (2000) Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers. Cancer Research, 60 (6). pp. 1483-1487. ISSN 0008-5472 . (Access to this publication is restricted)

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Abstract

The prevalence and sites of expression of the c-erbB-4 receptor have been determined by immunocytochemical staining in a series of 178 human breast cancers. Most tumors displayed cytoplasmic staining of variable intensity. When compared with adjacent normal tissue, 32 cases (18%) showed lower than normal expression, and 13 (7%) showed greater than normal expression. Nuclear immunoreactivity, confirmed by two different antibodies, was present in 87 cancers (49%) but was found in normal adjacent breast epithelial cells in <5% of cases. There were no significant associations with cytoplasmic or membrane immunoreactivity, but cases showing nuclear expression in >25% of cells were associated with good histological grade, epidermal growth factor receptor expression, c-erbB-3 positivity, cripto, amphiregulin, and transforming growth factor-alpha overexpression.

Item Type: Article
Uncontrolled keywords: Biological Markers/analysis Breast/chemistry Breast Neoplasms/*metabolism/pathology Cell Membrane/chemistry Cell Nucleus/*chemistry Cytoplasm/chemistry *Epidermal Growth Factor Female Glycoproteins/analysis Growth Substances/analysis Humans Immunohistochemistry *Intercellular Signaling Peptides and Proteins *Membrane Glycoproteins Neoplasm Invasiveness Neoplasm Proteins/analysis Nuclear Envelope/chemistry Receptor, Epidermal Growth Factor/analysis/*biosynthesis Receptor, erbB-3/analysis
Subjects: Q Science
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Bill Gullick
Date Deposited: 12 Jun 2008 11:53
Last Modified: 17 Apr 2014 14:38
Resource URI: http://kar.kent.ac.uk/id/eprint/3996 (The current URI for this page, for reference purposes)
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