Update on HER-2 as a target for cancer therapy: alternative strategies for targeting the epidermal growth factor system in cancer

Gullick, W.J. (2001) Update on HER-2 as a target for cancer therapy: alternative strategies for targeting the epidermal growth factor system in cancer. Breast Cancer Research, 3 (6). pp. 390-394. ISSN 1465-5411. (Full text available)

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http://dx.doi.org/10.1186/bcr328

Abstract

The epidermal growth factor (EGF) family of ligands and receptors interact to influence cell division, differentiation and motility. Much evidence supports their importance in causing and sustaining cell transformation in model systems and in human cancer. The exact mechanism by which this is achieved varies in different tumour types and from case to case. The EGF system is a target for new types of targeted chemotherapy. The choice of strategy will depend on the mechanism involved, however, and several approaches are under development or evaluation in clinical trials. Each will have a different spectrum of side effects and the potential for development of drug resistance.

Item Type: Article
Additional information: Free full-text article in PubMed Central and on Breast Cancer Research.
Uncontrolled keywords: cancer, chemotherapy, growth factor, growth factor receptor
Subjects: Q Science
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Bill Gullick
Date Deposited: 12 Jun 2008 11:09
Last Modified: 05 Sep 2011 23:34
Resource URI: http://kar.kent.ac.uk/id/eprint/3993 (The current URI for this page, for reference purposes)
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