Neuregulin 1-alpha expression in locally advanced breast cancer

Raj, E.H. and Skinner, A. and Mahji, U. and Nirmala, K.N. and Ravichandran, K. and Shanta, V. and Hurst, Helen C. and Gullick, William J. and Rajkumar, T. (2001) Neuregulin 1-alpha expression in locally advanced breast cancer. The Breast, 10 (1). pp. 41-45. ISSN 0960-9776. (Access to this publication is restricted)

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Official URL
http://dx.doi.org/10.1054/brst.2000.0182

Abstract

The human Neuregulin 1 (NRG1) gene encodes several alternatively spliced ligands that bind to both c-erbB-3 and c-erbB-4, members of the family of type 1 tyrosine kinase growth factor receptors. Antibodies raised to a synthetic peptide recognize selectively the alpha variant of NRG1. The NRG1-alpha isoforms' expression was studied in 115 locally advanced adenocarcinomas of the breast using immunohistochemistry. Absent or low levels of NRG1-alpha were found to be associated with poorer prognosis compared to tumours that had moderate to high levels of the protein.

Item Type: Article
Subjects: Q Science
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Bill Gullick
Date Deposited: 12 Jun 2008 10:27
Last Modified: 09 Jul 2014 14:13
Resource URI: http://kar.kent.ac.uk/id/eprint/3991 (The current URI for this page, for reference purposes)
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