Raj, E.H. and Skinner, A. and Mahji, U. and Nirmala, K.N. and Ravichandran, K. and Shanta, V. and Hurst, H.C. and Gullick, W.J. and Rajkumar, T. (2001) Neuregulin 1-alpha expression in locally advanced breast cancer. The Breast, 10 (1). pp. 41-45. ISSN 0960-9776.
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| Official URL http://dx.doi.org/10.1054/brst.2000.0182 |
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Abstract
The human Neuregulin 1 (NRG1) gene encodes several alternatively spliced ligands that bind to both c-erbB-3 and c-erbB-4, members of the family of type 1 tyrosine kinase growth factor receptors. Antibodies raised to a synthetic peptide recognize selectively the alpha variant of NRG1. The NRG1-alpha isoforms' expression was studied in 115 locally advanced adenocarcinomas of the breast using immunohistochemistry. Absent or low levels of NRG1-alpha were found to be associated with poorer prognosis compared to tumours that had moderate to high levels of the protein.
| Item Type: | Article |
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| Subjects: | Q Science R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group |
| Depositing User: | Bill Gullick |
| Date Deposited: | 12 Jun 2008 10:27 |
| Last Modified: | 05 Sep 2011 23:34 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/3991 (The current URI for this page, for reference purposes) |
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