HER-2 in breast cancer--methods of detection, clinical significance and future prospects for treatment

Rampaul, Raj and Pinder, S.E. and Gullick, William J. and Robertson, J.F. and Ellis, Ian O. (2002) HER-2 in breast cancer--methods of detection, clinical significance and future prospects for treatment. Critical Reviews in Oncology Hematology, 43 (3). pp. 231-244. ISSN 1040-8428 . (Access to this publication is restricted)

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http://dx.doi.org/10.1016/S1040-8428(01)00207-4

Abstract

The Human Epidermal Growth Factor (HER-2) oncogene encodes a transmembrane tyrosine kinase receptor with extensive homology to the Epidermal Growth Factor Receptor (EGFR) which is the prototypal member of this family of receptor tyrosine kinases. HER-2 gene amplification is found in 20-30% of breast cancers. Various methods such as immunohistochemistry, southern and slot blotting, enzyme immunoassays and fluorescence in situ hybridization have all been employed to evaluate HER-2 gene and protein abnormalities. Of these immunohistochemistry is the most frequently employed but there are valid indications for the other avaliable methods. However, it is prudent that whichever methods employed are standardized, especially those that possess may have a degree of subjectivity in their assesment.

Item Type: Article
Uncontrolled keywords: HER-2; Immunohistochemistry; FISH
Subjects: Q Science
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Bill Gullick
Date Deposited: 04 Sep 2008 14:02
Last Modified: 17 Jul 2014 08:31
Resource URI: http://kar.kent.ac.uk/id/eprint/3984 (The current URI for this page, for reference purposes)
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