Identification of surrogate markers for determining drug activity using proteomics

McClelland, C.M. and Gullick, William J. (2003) Identification of surrogate markers for determining drug activity using proteomics. Biochemical Society Transactions, 31 (Part 6). pp. 1488-1490. ISSN 0300-5127. (Access to this publication is restricted)

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Abstract

In a high proportion of human carcinomas overexpression of the EGFR (epidermal growth factor receptor), a receptor tyrosine kinase, represents a potential target for cancer treatment. EGFR is induced to dimerize through ligand binding which activates the tyrosine kinase activity of the receptor. This catalyses the transfer of ATP's gamma-phosphate to hydroxyl groups of tyrosine residues on the receptor, creating binding sites that recruit downstream signalling proteins. New drugs, SMTKIs (small-molecule tyrosine kinase inhibitors), have been designed to inhibit the tyrosine kinase activity of the receptor, producing an anti-tumour effect. The development of surrogate markers to determine the drug activity of these new inhibitors would be of great benefit in drug evaluation and in the subsequent management of patient disease. This review describes current treatments of cancer using tyrosine kinase inhibitors and the use of proteomic analysis to identify possible markers of activity of these new drugs.

Item Type: Article
Uncontrolled keywords: epidermal growth factor receptor (EGFR), proteomics, signal transduction, small-molecule tyrosine kinase inhibitor, surrogate marker, two-dimensional electrophoresis.
Subjects: Q Science
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Bill Gullick
Date Deposited: 03 Sep 2008 23:17
Last Modified: 21 May 2014 13:29
Resource URI: http://kar.kent.ac.uk/id/eprint/3980 (The current URI for this page, for reference purposes)
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