The epidermal growth factor receptor family

Bazley, L.A. and Gullick, W.J. (2005) The epidermal growth factor receptor family. Endocrine Related Cancer, 12 (Suppl 1). S17-S27. ISSN 1351-0088 . (Access to this publication is restricted)

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http://dx.doi.org/10.1677/erc.1.01032

Abstract

The epidermal growth factor receptor family consists of four receptor genes and at least 11 ligands, several of which are produced in different protein forms. They create an interacting system that has the ability to receive and process information that results in multiple outputs. The family has an important role in directing and coordinating many normal processes, including growth and development, normal tissue turnover and wound healing. Its members are also aberrantly activated by overexpression or mutation in many common human tumour types and as such have been the target for anticancer drug development.

Item Type: Article
Uncontrolled keywords: Animals Cytoplasm/metabolism Dimerization Humans Protein Conformation Receptor, Epidermal Growth Factor/*chemistry/genetics/*metabolism *Signal Transduction
Subjects: Q Science
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Bill Gullick
Date Deposited: 01 Sep 2008 20:51
Last Modified: 05 Sep 2011 23:34
Resource URI: http://kar.kent.ac.uk/id/eprint/3976 (The current URI for this page, for reference purposes)
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