Chobotova, K. and Karpovich, N. and Carver, J. and Manek, S. and Gullick, W.J. and Barlow, D.H. and Mardon, H.J. (2005) Heparin-binding epidermal growth factor and its receptors mediate decidualization and potentiate survival of human endometrial stromal cells. Journal of Clinical Endocrinology and Metabolism, 90 (2). pp. 913-919. ISSN 0021-972X .
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Heparin-binding epidermal growth factor (HB-EGF) has pleiotropic biological functions in many tissues, including those of the female reproductive tract. It facilitates embryo development and mediates implantation and is thought to have a function in endometrial receptivity and maturation. The mature HB-EGF molecule manifests its activity as either a soluble factor (sol-HB-EGF) or a transmembrane precursor (tm-HB-EGF) and can bind two receptors, EGFR and ErbB4/HER4. In this study, we identify factors that modulate expression of HB-EGF, EGFR, and ErbB4 in endometrial stromal cells in vitro. We demonstrate that levels of sol- and tm-HB-EGF, EGFR, and ErbB4 are increased by cAMP, a potent inducer of decidualization of the endometrial stroma. We also show that production of sol- and tm-HB-EGF is differentially modulated by TNF alpha and TGF beta. Our data suggest that HB-EGF has a function in endometrial maturation in mediating decidualization and attenuating TNF alpha- and TGF beta-induced apoptosis of endometrial stromal cells.
|Uncontrolled keywords:||Heparin-binding epidermal growth factor; ErbB4; Implantation|
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group|
|Depositing User:||Bill Gullick|
|Date Deposited:||01 Sep 2008 20:39|
|Last Modified:||05 Sep 2011 23:34|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/3975 (The current URI for this page, for reference purposes)|
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