Rampaul, R.S. and Pinder, S.E. and Nicholson, R.I. and Gullick, W.J. and Robertson, J.F. and Ellis, I.O. (2005) Clinical value of epidermal growth factor receptor expression in primary breast cancer. Advances in Anatomic Pathology, 12 (5). pp. 271-273. ISSN 1072-4109.
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EGFR expression in primary breast cancer has been extensively investigated for its prognostic and predictive value. However overall there is no consensus on its potential to guide such prognostication. This is largely because of the great heterogeneity in study designs and methods used to assay the EGFR protein. The impetus to standardize such studies is much needed as there are now several tyrosine kinase inhibitors directed against the EGF receptor and phase II trials are showing significant promise.
|Uncontrolled keywords:||Adenocarcinoma/diagnosis/*metabolism Breast Neoplasms/diagnosis/*metabolism Female Gene Expression Regulation, Neoplastic Humans Predictive Value of Tests Prognosis Receptor, Epidermal Growth Factor/genetics/*metabolism|
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group|
|Depositing User:||Bill Gullick|
|Date Deposited:||30 Aug 2008 21:33|
|Last Modified:||05 Sep 2011 23:34|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/3973 (The current URI for this page, for reference purposes)|
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