Mutations of the epidermal growth factor receptor in non-small cell lung cancer -- search and destroy

Chan, Samuel K. W. and Gullick, William J. and Hill, Mark E. (2006) Mutations of the epidermal growth factor receptor in non-small cell lung cancer -- search and destroy. European Journal of Cancer, 42 (1). pp. 17-23. ISSN 0959-8049. (Access to this publication is restricted)

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http://dx.doi.org/10.1016/j.ejca.2005.07.031

Abstract

The targeting of the ATP binding pocket of the epidermal growth factor receptor (EGFR) tyrosine kinase, by the small molecule drugs gefitinib and erlotinib, represents a promising new therapeutic strategy in non-small cell lung cancer. However, it is now apparent that only a subset of patients responds to such treatment. Two publications in early 2004 reported the presence of activating mutations in the EGFR tyrosine kinase gene conferring exquisite sensitivity to these drugs. Several publications have since reported prospective data consistent with this finding. This brief review summarises the mutation data from 15 such studies in terms of mutation frequency by clinicopathological features and correlation with response to tyrosine kinase inhibition. A new paradigm for the routine detection of such mutations is needed to facilitate patient selection for treatment and further studies.

Item Type: Article
Uncontrolled keywords: EGFR; NSCLC; Targeted therapy; Gefitinib; Erlotinib; Mutation; Tyrosine kinase
Subjects: Q Science
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Bill Gullick
Date Deposited: 30 Aug 2008 20:57
Last Modified: 21 May 2014 13:27
Resource URI: http://kar.kent.ac.uk/id/eprint/3972 (The current URI for this page, for reference purposes)
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