The role of the epidermal growth factor receptor in breast cancer

Chan, S.K. and Hill, M.E. and Gullick, W.J. (2006) The role of the epidermal growth factor receptor in breast cancer. Journal of Mammary Gland Biology and Neoplasia, 11 (1). pp. 3-11. ISSN 1083-3021. (Access to this publication is restricted)

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Official URL
http://dx.doi.org/10.1007/s10911-006-9008-2

Abstract

Recent trials of drug therapy targeting the erbB receptor HER2 have met with success in breast cancer. The epidermal growth factor receptor or EGFR is a closely related receptor from this same family that is involved in cellular signal transduction and tumor cell growth and survival. Emerging evidence indicates that EGFR is implicated in the development of hormone-resistant breast cancer, and that its activity is intertwined with estrogen receptor. Here, the role of EGFR in breast cancer is reviewed, and data from selected clinical trials of signal transduction inhibition of this cellular target are summarized.

Item Type: Article
Uncontrolled keywords: Breast - ErbB - EGFR - Signal transduction - Hormone resistance - Gefitinib - Erlotinib
Subjects: Q Science
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Bill Gullick
Date Deposited: 30 Aug 2008 20:43
Last Modified: 05 Sep 2011 23:34
Resource URI: http://kar.kent.ac.uk/id/eprint/3971 (The current URI for this page, for reference purposes)
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