Chan, S.K. and Hill, M.E. and Gullick, W.J. (2006) The role of the epidermal growth factor receptor in breast cancer. Journal of Mammary Gland Biology and Neoplasia, 11 (1). pp. 3-11. ISSN 1083-3021.
|
PDF (The Role of the Epidermal Growth Factor Receptor)
Restricted to Repository staff only |
|
|
| Contact us about this Publication
Download (173Kb)
|
![[img]](http://kar.kent.ac.uk/style/images/fileicons/application_pdf.png) |
| Official URL http://dx.doi.org/10.1007/s10911-006-9008-2 |
|
Abstract
Recent trials of drug therapy targeting the erbB receptor HER2 have met with success in breast cancer. The epidermal growth factor receptor or EGFR is a closely related receptor from this same family that is involved in cellular signal transduction and tumor cell growth and survival. Emerging evidence indicates that EGFR is implicated in the development of hormone-resistant breast cancer, and that its activity is intertwined with estrogen receptor. Here, the role of EGFR in breast cancer is reviewed, and data from selected clinical trials of signal transduction inhibition of this cellular target are summarized.
| Item Type: | Article |
|---|---|
| Uncontrolled keywords: | Breast - ErbB - EGFR - Signal transduction - Hormone resistance - Gefitinib - Erlotinib |
| Subjects: | Q Science R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group |
| Depositing User: | Bill Gullick |
| Date Deposited: | 30 Aug 2008 20:43 |
| Last Modified: | 05 Sep 2011 23:34 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/3971 (The current URI for this page, for reference purposes) |
- Depositors only (login required):
