Radiotherapy and Cellular Signalling

Lewanski, Conrad R. and Gullick, William J. (2001) Radiotherapy and Cellular Signalling. Lancet Oncology, 2 (6). pp. 366-370. ISSN 1470-2045. (Access to this publication is restricted)

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http://dx.doi.org/10.1016/S1470-2045(00)00391-0

Abstract

Developments in cellular and molecular biology in the past decade have increased our understanding of the processes by which cells respond to ionising radiation. Cells use complex protein signalling systems that recognise radiation damage to DNA and plasma membrane lipids. When damage is found, it leads to the activation of various intracellular pathways that modulate the activity of genes controlling ceflular responses such as apoptosis, cell-cycle arrest, or repair. Numerous molecular targets may be activated or inhibited in an attempt to upregulatre or downregulate the radiation response. In this review, we discuss some of the new compounds and techniques for manipulating the cell's response to radiation.

Item Type: Article
Additional information: Review Article
Subjects: Q Science
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: Bill Gullick
Date Deposited: 25 Sep 2009 14:29
Last Modified: 21 May 2014 13:30
Resource URI: http://kar.kent.ac.uk/id/eprint/3952 (The current URI for this page, for reference purposes)
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