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Antibodies to factor XII: a possible predictive marker for recurrent foetal loss

Jones, David Wynne, Gallimore, Michael J., Winter, Mark (2003) Antibodies to factor XII: a possible predictive marker for recurrent foetal loss. Immunobiology, 207 (1). pp. 43-46. ISSN 0171-2985. (doi:10.1078/0171-2985-00207) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:3943)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1078/0171-2985-00207

Abstract

Antibodies to factor XII (FXIIabs) have been demonstrated in some patients with the antiphospholipid syndrome (APS). The presence of these antibodies were shown to lead to statistically significantly reduced levels of FXII (p=0.02). In an extension to this study forty female patients with either primary APS (n=26) or systemic lupus erythematosus (APS positive) (n=14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2-glycoprotein I and factor XII. Twenty one of the forty patients had a history of foetal loss (>2, mean=2.6). Lupus anticoagulant positivity showed a weak association with foetal loss (odds ratio=1.1). While there was no association between the presence of antibodies to cardiolipin or beta 2-glycoprotein I with foetal loss, antibodies to factor XII showed a strong and statistically significant association (odds ratio=5.4, p=0.025).

Item Type: Article
DOI/Identification number: 10.1078/0171-2985-00207
Additional information: Article 654HP English Times Cited:7 Cited References Count:21
Uncontrolled keywords: ANTIPHOSPHOLIPID ANTIBODIES LUPUS ANTICOAGULANT CONTACT SYSTEM COMPLEX FIBRINOLYSIS COAGULATION ACTIVATION
Subjects: Q Science > Q Science (General)
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: D.W. Jones
Date Deposited: 03 Sep 2008 23:04 UTC
Last Modified: 16 Nov 2021 09:42 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/3943 (The current URI for this page, for reference purposes)

University of Kent Author Information

Jones, David Wynne.

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