Jones, D.W. and Gallimore, M.J. and Winter, M. (2003) Antibodies to factor XII: a possible predictive marker for recurrent foetal loss. IMMUNOBIOLOGY, 207 (1). pp. 43-46. ISSN 0171-2985.
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Antibodies to factor XII (FXIIabs) have been demonstrated in some patients with the antiphospholipid syndrome (APS). The presence of these antibodies were shown to lead to statistically significantly reduced levels of FXII (p=0.02). In an extension to this study forty female patients with either primary APS (n=26) or systemic lupus erythematosus (APS positive) (n=14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2-glycoprotein I and factor XII. Twenty one of the forty patients had a history of foetal loss (>2, mean=2.6). Lupus anticoagulant positivity showed a weak association with foetal loss (odds ratio=1.1). While there was no association between the presence of antibodies to cardiolipin or beta 2-glycoprotein I with foetal loss, antibodies to factor XII showed a strong and statistically significant association (odds ratio=5.4, p=0.025).
|Additional information:||Article 654HP English Times Cited:7 Cited References Count:21|
|Uncontrolled keywords:||ANTIPHOSPHOLIPID ANTIBODIES LUPUS ANTICOAGULANT CONTACT SYSTEM COMPLEX FIBRINOLYSIS COAGULATION ACTIVATION|
|Subjects:||Q Science > Q Science (General)|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences
Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
|Depositing User:||D Wynne Jones|
|Date Deposited:||03 Sep 2008 23:04|
|Last Modified:||08 Jun 2012 14:15|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/3943 (The current URI for this page, for reference purposes)|
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