Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus.

Cinatl, Jindrich, Hoever, Gerold, Morgenstern, Birgit, Preiser, Wolfgang, Vogel, Jens-Uwe, Hofmann, W-K, Bauer, Gabriele, Michaelis, Martin, Rabenau, Holger F, Doerr, Hans Wilhelm and others. (2004) Infection of cultured intestinal epithelial cells with severe acute respiratory syndrome coronavirus. Cellular and Molecular Life Sciences, 61 (16). pp. 2100-12. ISSN 1420-9071. (doi:10.1007/s00018-004-4222-9) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:34118)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL: http://dx.doi.org10.1007/s00018-004-4222-9

Abstract

To identify a model for the study of intestinal pathogenesis of severe acute respiratory syndrome (SARS) we tested the sensitivity of six human intestinal epithelial cell lines to infection with SARS coronavirus (SARS-CoV). In permissive cell lines, effects of SARS-CoV on cellular gene expression were analysed using high-density oligonucleotide arrays. Caco-2 and CL-14 cell lines were found to be highly permissive to SARS-CoV, due to the presence of angiotensin-converting enzyme 2 as a functional receptor. In both cell lines, SARS-CoV infection deregulated expression of cellular genes which may be important for the intestinal pathogenesis of SARS.

Item Type:	Article
DOI/Identification number:	10.1007/s00018-004-4222-9
Subjects:	Q Science > QR Microbiology > QR355 Virology
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	Martin Michaelis
Date Deposited:	05 Jun 2013 20:20 UTC
Last Modified:	16 Nov 2021 10:11 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/34118 (The current URI for this page, for reference purposes)

University of Kent Author Information

Michaelis, Martin.

Creator's ORCID:	https://orcid.org/0000-0002-5710-5888
CReDIT Contributor Roles:

Depositors only (login required):

Altmetric

Download Statistics

Total unique views for this document in KAR since July 2020. For more details click on the image.