Skip to main content

The study of heterosubtypic neutralising antibody responses against H5N1 influenza viruses in human subjects using a comparative serology approach

Molesti, Eleonora, Ferrara, Francesca, Montomoli, Emanuele, Temperton, Nigel J. (2013) The study of heterosubtypic neutralising antibody responses against H5N1 influenza viruses in human subjects using a comparative serology approach. In: Society for General Microbiology Spring Meeting, 25-28 Mar 2013, Manchester. (Unpublished) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:33650)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://www.sgm.ac.uk/en/events/conferences/index.c...

Abstract

The continuous rapid genetic and antigenic evolution of H5 subtype

influenza viruses has major implications for the sensitivity of serological

assays and can limit the efficacy of pre-pandemic human vaccines and the

ability to undertake effective sero-surveillance in susceptible populations.

A panel of serum samples collected from the Italian population between

1992 and 2007 and previously found to be positive for antibodies against

H5N1 as determined by SRH, were evaluated using pseudotype based

neutralisation assays in combination with haemagglutination-inhibition

assays using a clade 1 and a clade 2 H5N1 serological antigen. From

the results obtained it can be concluded that the pseudotype assay

measures cross-reactive antibody responses that are not picked up with

the HI assay. Both assays measure antibodies with different (functional)

specificities contributing to a comprehensive analysis of humoral

immunity to influenza viruses.

Item Type: Conference or workshop item (Speech)
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Nigel Temperton
Date Deposited: 22 Apr 2013 12:34 UTC
Last Modified: 16 Nov 2021 10:11 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/33650 (The current URI for this page, for reference purposes)

University of Kent Author Information

Molesti, Eleonora.

Creator's ORCID:
CReDIT Contributor Roles:

Ferrara, Francesca.

Creator's ORCID:
CReDIT Contributor Roles:

Temperton, Nigel J..

Creator's ORCID: https://orcid.org/0000-0002-7978-3815
CReDIT Contributor Roles:
  • Depositors only (login required):

Total unique views for this document in KAR since July 2020. For more details click on the image.