Simulating complex intracellular processes using object-oriented computational modelling

Johnson, Colin G. and Goldman, Jacki P. and Gullick, William J. (2004) Simulating complex intracellular processes using object-oriented computational modelling. Progress in Biophysics and Molecular Biology, 86 (3). pp. 379-406. ISSN 0079-6107 . (Access to this publication is restricted)

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http://dx.doi.org/10.1016/j.pbiomolbio.2003.11.001

Abstract

The aim of this paper is to give an overview of computer modelling and simulation in cellular biology, in particular as applied to complex biochemical processes within the cell. This is illustrated by the use of the techniques of object-oriented modelling, where the computer is used to construct abstractions of objects in the domain being modelled, and these objects then interact within the computer to simulate the system and allow emergent properties to be observed. The paper also discusses the role of computer simulation in understanding complexity in biological systems, and the kinds of information which can be obtained about biology via simulation.

Item Type: Article
Uncontrolled keywords: Computational modelling; Object-oriented methods; Intracellular processes; Protein–protein interactions
Subjects: Q Science
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Sue Davies
Date Deposited: 19 Dec 2007 17:46
Last Modified: 21 May 2014 13:19
Resource URI: http://kar.kent.ac.uk/id/eprint/33 (The current URI for this page, for reference purposes)
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