Prior, M. and Thatcher, N. and Morris, P. and Reese, T. and Bachelard, H. (2005) The phenomenon of "pe-ischaemic conditioning" in the brain only partly involves the NMDA receptor: A magnetic resonance study. Neurochemical Research, 30 (10). pp. 1219-1225. ISSN 03643190 (ISSN) .
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We have investigated in more detail our previous observations on a form of ischaemic pre-conditioning "metabolic adaptation", i.e.-that sequential metabolic insults (hypoxia followed 40 min later by combined hypoxia + hypoglycaemia, or vice versa) are less injurious (monitored by increased [Ca 2+] i and decreased PCr) than the immediate combined insult. We have now observed that the "adaptation" occurs between 10 and 20 min. Pre-treatment of the tissues with 10 Î¼M-MK801 showed that it had no effect on the increase in [Ca 2+] i caused by the sequential insult and only partially blocked the increase observed by exposure to the immediate combined insult. Exposure to both the delayed and immediate combined insults with low extracellular Ca 2+ resulted in a two-fold increase in [Ca 2+] i , similar to the increase observed with normal extracellular Ca 2+ in the presence of MK801. The results are discussed in terms of the possible origins of the increases in [Ca 2+] i.
|Uncontrolled keywords:||Calcium, Ischaemia, MK 801, Nifedipine, NMDA receptor, calcium channel, calcium ion, dizocilpine, n methyl dextro aspartic acid receptor, animal tissue, article, brain hypoxia, brain infarction, brain metabolism, controlled study, extracellular calcium, hypoglycemia, neuropharmacology, neuroprotection, nonhuman, nuclear magnetic resonance, pharmacological blocking, priority journal, stress, Animalia|
|Subjects:||Q Science > QP Physiology (Living systems) > QP517 Biochemistry|
|Divisions:||Central Services > Templeman Library|
|Depositing User:||Nicola Cooper|
|Date Deposited:||04 Dec 2012 16:47|
|Last Modified:||30 Apr 2013 13:51|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/32296 (The current URI for this page, for reference purposes)|
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