Sen, Tapas and Bruce, Ian J. (2012) Surface engineering of nanoparticles in suspension for particle based bio-sensing. Scientific Reports, 2 . ISSN 2045-2322.
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Surface activation of nanoparticles in suspension using amino organosilane has been carried out via strict control of a particle surface ad-layer of water using a simple but efficient protocol ‘Tri-phasic Reverse Emulsion’ (TPRE). This approach produced thin and ordered layers of particle surface functional groups which allowed the efficient conjugation of biomolecules. When used in bio-sensing applications, the resultant conjugates were highly efficient in the hybrid capture of complementary oligonucleotides and the detection of food borne microorganism. TPRE overcomes a number of fundamental problems associated with the surface modification of particles in aqueous suspension viz. particle aggregation, density and organization of resultant surface functional groups by controlling surface condensation of the aminosilane. The approach has potential for application in areas as diverse as nanomedicine, to food technology and industrial catalysis.
|Additional information:||Article number: 564|
|Uncontrolled keywords:||DNA; Nanobiotechnology; Surface patterning|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences|
|Depositing User:||Sue Davies|
|Date Deposited:||06 Nov 2012 16:51|
|Last Modified:||21 Mar 2013 15:48|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/32104 (The current URI for this page, for reference purposes)|
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