Regulated translational bypass of stop codons in yeast

von der Haar, Tobias and Tuite, Mick F. (2007) Regulated translational bypass of stop codons in yeast. Trends in Microbiology, 15 (2). pp. 78-86. ISSN 0966-842X . (The full text of this publication is not available from this repository)

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Abstract

Stop codons are used to signal the ribosome to terminate the decoding of an mRNA template. Recent studies on translation termination in the yeast Saccharomyces cerevisiale have not only enabled the identification of the key components of the termination machinery, but have also revealed several regulatory mechanisms that might enable the controlled synthesis of C-terminally extended polypeptides via stop-codon readthrough. These include both genetic and epigenetic mechanisms. Rather than being a translation 'error', stop-codon readthrough can have important effects on other cellular processes such as mRNA degradation and, in some cases, can confer a beneficial phenotype to the cell

Item Type: Article
Subjects: Q Science > QR Microbiology
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: Maureen Cook
Date Deposited: 14 May 2008 07:14
Last Modified: 10 Jun 2014 11:11
Resource URI: http://kar.kent.ac.uk/id/eprint/3145 (The current URI for this page, for reference purposes)
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