Attenuation of Vibrio fischeri Quorum Sensing Using Rationally Designed Polymers

Piletska, Elena V. and Stavroulakis, Georgios and Karim, Kal and Whitcombe, Michael J. and Chianella, Iva and Sharma, Anant and Eboigbodin, Kevin E. and Robinson, Gary K. and Piletsky, Sergey A. (2010) Attenuation of Vibrio fischeri Quorum Sensing Using Rationally Designed Polymers. Biomacromolecules, 11 (4). pp. 975-980. ISSN 1525-7797. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1021/bm901451j

Abstract

A first attempt to attenuate the quorum sensing (QS) of a marine heterotroph microorganism, Vibrio fischeri, using signal molecule-sequestering polymers (SSPs) is presented. A set of rationally designed polymers with affinity toward a signal molecule of V. fischeri, N-(β-ketocaproyl)-l-homoserine lactone (3-oxo-C6-AHL) was produced. It is reported that computationally designed polymers could sequester a signal molecule of V. fischeri and prevent QS-controlled phenotypes (in this case, bioluminescence) from being up-regulated. It was proven that the attenuation of bioluminescence of V. fischeri was due to sequestration of the signal molecule by specific polymers and not due to the toxicity of polymer or nonspecific depletion of nutrients. The ability to disrupt the bacterial communication using easy to synthesize and chemically inert polymers could provide a new concept for the development of pharmaceuticals and susceptible device coatings such as catheters.

Item Type: Article
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: Sue Davies
Date Deposited: 09 Oct 2012 08:35
Last Modified: 31 Jan 2013 09:28
Resource URI: http://kar.kent.ac.uk/id/eprint/31408 (The current URI for this page, for reference purposes)
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