Cisplatin-Resistant Neuroblastoma Cells Express Enhanced Levels of Epidermal Growth Factor Receptor (EGFR) and Are Sensitive to Treatment with EGFR-Specific Toxins

Michaelis, Martin and Bliss, Jennifer and Arnold, Sonja C. and Hinsch, Nora and Rothweiler, Florian and Deubzer, Hedwig and Witt, Olaf and Langer, Klaus and Doerr, Hans W. and Wels, Winfried S. and Cinatl, Jindrich Jr (2008) Cisplatin-Resistant Neuroblastoma Cells Express Enhanced Levels of Epidermal Growth Factor Receptor (EGFR) and Are Sensitive to Treatment with EGFR-Specific Toxins. Clinical Cancer Research, 14 (20). pp. 6531-6537. ISSN 1078-0432. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1158/1078-0432.CCR-08-0821

Abstract

Neuroblastomas frequently show expression of the epidermal growth factor receptor (EGFR) and may therefore be susceptible to EGFR-targeted therapies. Here, EGFR expression and functionality was investigated in parental chemosensitive neuroblastoma cell lines (UKF-NB-3, IMR-32, NLF, SH-SY5Y) and their cisplatin-resistant sublines (UKF-NB-3rCDDP1000, IMR-32rCDDP1000, NLFrCDDP1000, and SH-SY5YrCDDP500). Moreover, the EGFR antibody cetuximab, the EGFR tyrosine kinase inhibitor Tyrphostin B46, and recombinant EGFR-targeted toxins were investigated for their influence on the viability and growth of neuroblastoma cells.

Item Type: Article
Uncontrolled keywords: neuroblastoma; epithelial growth factor; epithelial growth factor receptor; toxin; chemoresistance
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: Sue Davies
Date Deposited: 08 Oct 2012 13:52
Last Modified: 11 Apr 2014 15:38
Resource URI: http://kar.kent.ac.uk/id/eprint/31386 (The current URI for this page, for reference purposes)
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