Expression of neuregulin 4 splice variants in normal human tissues and prostate cancer and their effects on cell motility

Hayes, N.V.L. and Blackburn, E. and Boyle, M.M. and Russell, G.A. and Frost, T.M. and Morgan, B.J.T. and Gullick, W.J. (2010) Expression of neuregulin 4 splice variants in normal human tissues and prostate cancer and their effects on cell motility. Endocrine Related Cancer, 18 (1). pp. 39-49. ISSN 1351-0088. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1677/ERC-10-0112

Abstract

The neuregulin 4 gene encodes at least five different variants (designated A1, A2, B1, B2 and B3) produced as a result of alternative splicing. We have determined their sites of expression in normal human adult tissues using isoform-specific antibodies. Their expression is cell type specific and differs in subcellular location suggesting that they may have varied functions in these contexts. We have shown in a panel of prostate cancers that each form is present to differing degrees, and that principal component analysis indicates that there are three patterns of expression. Some isoforms were positively correlated with high prostate-specific antigen levels and others were inversely associated with Gleason score. Synthetic, refolded A forms promoted lamellipodia and filopodia formation in cells expressing the ErbB4 (CTa) receptor and stimulated cell motility in wound healing assays. The data suggest that the different forms have varied sites of expression and function, and this includes effects on cell architecture and motility.

Item Type: Article
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Sue Davies
Date Deposited: 08 Oct 2012 13:29
Last Modified: 19 Mar 2014 09:30
Resource URI: http://kar.kent.ac.uk/id/eprint/31379 (The current URI for this page, for reference purposes)
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