Identification of new surfaces of cofilin that link mitochondrial function to the control of multi-drug resistance

Kotiadis, Vassilios N. and Leadsham, Jane E. and Bastow, Emma L. and Gheeraert, Aline and Whybrew, Jennafer M. and Bardsley, Martin and Lappalainen, Pekka and Gourlay, Campbell W. (2012) Identification of new surfaces of cofilin that link mitochondrial function to the control of multi-drug resistance. Journal of Cell Science, 125 (9). pp. 2288-2299. ISSN 0021-9533. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1242/jcs.099390

Abstract

ADF/cofilin family proteins are essential regulators of actin cytoskeletal dynamics. Recent evidence also implicates cofilin in the regulation of mitochondrial function. Here, we identify new functional surfaces of cofilin that are linked with mitochondrial function and stress responses in the budding yeast Saccharomyces cerevisiae. Our data link surfaces of cofilin that are involved in separable activities of actin filament disassembly or stabilisation, to the regulation of mitochondrial morphology and the activation status of Ras, respectively. Importantly, charge alterations to conserved surfaces of cofilin that do not interfere with its actin regulatory activity lead to a dramatic increase in respiratory function that triggers a retrograde signal to upregulate a battery of ABC transporters and concurrent metabolic changes that support multi-drug resistance. We hypothesise that cofilin functions within a bio-sensing system that connects the cytoskeleton and mitochondrial function to environmental challenge.

Item Type: Article
Uncontrolled keywords: ROS; Actin; Cofilin; Mitochondria; Multi-drug resistance; Yeast
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: Sue Davies
Date Deposited: 08 Oct 2012 11:20
Last Modified: 23 Jun 2014 09:23
Resource URI: http://kar.kent.ac.uk/id/eprint/31358 (The current URI for this page, for reference purposes)
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