Zabet, Nicolae Radu and Chu, Dominique F. (2010) Computational limits to binary genes. J. R. Soc. Interface, 7 . pp. 182-196.
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We analyse the trade-off between the speed with which a gene can propagate information, the noise of its output and its metabolic cost. Our main finding is that for any given level of metabolic cost there is an optimal trade-off between noise and processing speed. Any system with a non-vanishing leak expression rate is suboptimal, i.e. it will exhibit higher noise and/or slower speed than leak-free systems with the same metabolic cost. We also show that there is an optimal Hill coefficient h which minimizes noise and metabolic cost at fixed speeds, and an optimal threshold K which minimizes noise.
|Uncontrolled keywords:||determinacy analysis, Craig interpolants|
|Subjects:||Q Science > QA Mathematics (inc Computing science) > QA 76 Software, computer programming,|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Computing > Computational Intelligence Group|
|Depositing User:||Dominique Chu|
|Date Deposited:||21 Sep 2012 09:49|
|Last Modified:||21 Sep 2012 09:49|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/30663 (The current URI for this page, for reference purposes)|
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