Zabet, Nicolae Radu and Hone, Andrew N. W. and Chu, Dominique F. (2010) Design Principles of Transcriptional Logic Circuits. In: Artificial Life XII Proceedings of the Twelfth International Conference on the Synthesis and Simulation of Living Systems.
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| Official URL http://www.cs.kent.ac.uk/pubs/2010/3036 |
Abstract
Using a set of genetic logic gates (AND, OR and XOR), we constructed a binary full-adder. The optimality analysis of the full-adder showed that, based on the position of the regulation threshold, the system displays different optimal configurations for speed and accuracy under fixed metabolic cost. In addition, the analysis identified an optimal trade-off curve bounded by these two optimal configurations. Any configuration outside this optimal trade-off curve is sub-optimal in both speed and accuracy. This type of analysis represents a useful tool for synthetic biologists to engineer faster, more accurate and cheaper genes.
| Item Type: | Conference or workshop item (UNSPECIFIED) |
|---|---|
| Additional information: | Freely available for download at: http://mitpress.mit.edu/catalog/item/default.asp?ttype=2&tid=12433 |
| Uncontrolled keywords: | determinacy analysis, Craig interpolants |
| Subjects: | Q Science > QA Mathematics (inc Computing science) > QA 76 Software, computer programming, |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Computing > Computational Intelligence Group |
| Depositing User: | Dominique Chu |
| Date Deposited: | 21 Sep 2012 09:49 |
| Last Modified: | 21 Sep 2012 09:49 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/30641 (The current URI for this page, for reference purposes) |
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