A Multiscale Approach to the Elastic Moduli of Biomembrane

Fraternali, F. and Marcelli, G. (2012) A Multiscale Approach to the Elastic Moduli of Biomembrane. Biomechanics and Modeling in Mechanobiology, 11 (7). pp. 1097-1108. ISSN 1617-7959. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1007/s10237-012-0376-9

Abstract

We develop equilibrium fluctuation formulae for the isothermal elastic moduli of discrete biomembrane models at different scales. We account for the coupling of large stretching and bending strains of triangulated network models endowed with harmonic and dihedral angle potentials, on the basis of the discrete-continuum approach presented in Schmidt and Fraternali (J Mech Phys Solids 60:172–180, 2012). We test the proposed equilibrium fluctuation formulae with reference to a coarse-grained molecular dynamics model of the red blood cell (RBC) membrane (Marcelli et al. in Biophys J 89:2473–2480, 2005; Hale et al. in Soft Matter 5:3603–3606, 2009), employing a local maximum-entropy regularization of the fluctuating configurations (Fraternali et al. in J Comput Phys 231:528–540, 2012). We obtain information about membrane stiffening/softening due to stretching, curvature, and microscopic undulations of the RBC model. We detect local dependence of the elastic moduli over the RBC membrane, establishing comparisons between the present theory and different approaches available in the literature.

Item Type: Article
Uncontrolled keywords: Biomembranes, Bending, Stretching, Thermal fluctuations, Red blood cell model
Subjects: Q Science > QH Natural history > QH324.2 Computational biology
Divisions: Faculties > Science Technology and Medical Studies > School of Engineering and Digital Arts > Instrumentation, Control and Embedded Systems
Depositing User: J. Harries
Date Deposited: 26 Apr 2012 14:02
Last Modified: 04 Oct 2012 14:10
Resource URI: http://kar.kent.ac.uk/id/eprint/29359 (The current URI for this page, for reference purposes)
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