Atacamycins A–C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38*

Nachtigall, Jonny and Kulik, Andreas and Helaly, Soleiman and Bull, Alan T. and Goodfellow, Michael and Asenjo, Juan A. and Maier, Armin and Wiese, Jutta and Imhoff, Johannes F. and Sussmuth, Roderich D. and Fiedler, Hans-Peter (2011) Atacamycins A–C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38*. Journal of Antibiotics, 64 (12). pp. 775-780. ISSN 0021-8820. (The full text of this publication is not available from this repository)

The full text of this publication is not available from this repository. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1038/ja.2011.96

Abstract

Three new 22-membered macrolactone antibiotics, atacamycins A–C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of Chile. The metabolites were discovered in our HPLC-diode array screening and isolated from the mycelium by extraction and chromatographic purification steps. The structures were determined by mass spectrometry and NMR experiments. Atacamycins A, B and C exhibited moderate inhibitory activities against the enzyme phosphodiesterase (PDE-4B2), whereas atacamycin A showed a moderate antiproliferative activity against adeno carcinoma and breast carcinoma cells.

Item Type: Article
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: Sue Davies
Date Deposited: 27 Mar 2012 15:28
Last Modified: 11 Apr 2014 15:29
Resource URI: http://kar.kent.ac.uk/id/eprint/29214 (The current URI for this page, for reference purposes)
  • Depositors only (login required):