Nachtigall, J. and Kulik, A. and Helaly, S. and Bull, A.T. and Goodfellow, M. and Asenjo, J.A. and Maier, A. and Wiese, J. and Imhoff, J.F. and Sussmuth, R.D. and Fiedler, H.P. (2011) Atacamycins A–C, 22-membered antitumor macrolactones produced by Streptomyces sp. C38*. Journal of Antibiotics, 64 (12). pp. 775-780. ISSN 0021-8820.
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| Official URL http://dx.doi.org/10.1038/ja.2011.96 |
Abstract
Three new 22-membered macrolactone antibiotics, atacamycins A–C, were produced by Streptomyces sp. C38, a strain isolated from a hyper-arid soil collected from the Atacama Desert in the north of Chile. The metabolites were discovered in our HPLC-diode array screening and isolated from the mycelium by extraction and chromatographic purification steps. The structures were determined by mass spectrometry and NMR experiments. Atacamycins A, B and C exhibited moderate inhibitory activities against the enzyme phosphodiesterase (PDE-4B2), whereas atacamycin A showed a moderate antiproliferative activity against adeno carcinoma and breast carcinoma cells.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Biosciences |
| Depositing User: | Sue Davies |
| Date Deposited: | 27 Mar 2012 15:28 |
| Last Modified: | 29 May 2012 09:57 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/29214 (The current URI for this page, for reference purposes) |
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