Tuite, M.F. and Marchante, R. and Kushnirov, V.V. (2011) Fungal Prions: Structure, Function and Propagation. Topics in Current Chemistry, 305 . pp. 257-298. ISSN 0340-1022.
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Prions are not uniquely associated with rare fatal neurodegenerative diseases in the animal kingdom; prions are also found in fungi and in particular the yeast Saccharomyces cerevisiae. As with animal prions, fungal prions are proteins able to exist in one or more self-propagating alternative conformations, but show little primary sequence relationship with the mammalian prion protein PrP. Rather, fungal prions represent a relatively diverse collection of proteins that participate in key cellular processes such as transcription and translation. Upon switching to their prion form, these proteins can generate stable, sometimes beneficial, changes in the host cell phenotype. Much has already been learnt about prion structure, and propagation and de novo generation of the prion state through studies in yeast and these findings are reviewed here.
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences|
|Depositing User:||Sue Davies|
|Date Deposited:||27 Mar 2012 14:42|
|Last Modified:||28 Mar 2012 10:17|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/29210 (The current URI for this page, for reference purposes)|
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