Outbreak of a South West Pacific clone Panton–Valentine leucocidin-positive meticillin-resistant Staphylococcus aureus infection in a UK neonatal intensive care unit

Ali, H. and Nash, J.Q. and Kearns, A.M. and Pichon, Bruno and Vasu, Vimal and Nixon, Z. and Burgess, Anthony W. and Weston, D. and Sedgwick, J. and Ashford, G. and Mühlschlegel, Fritz A. (2012) Outbreak of a South West Pacific clone Panton–Valentine leucocidin-positive meticillin-resistant Staphylococcus aureus infection in a UK neonatal intensive care unit. Journal of Hospital Infection, 80 (4). pp. 293-298. ISSN 0195-6701. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1016/j.jhin.2011.12.019

Abstract

Background Panton–Valentine leucocidin-positive meticillin-resistant Staphylococcus aureus (PVL-MRSA) has become a globally common cause of community-acquired infections. Aim We report an outbreak of PVL-MRSA in a regional neonatal unit in the UK involving three babies and three staff members. Methods Quinolone susceptibility was helpful in identifying potential PVL-MRSA but toxin gene profiling and sequence-based typing were required to distinguish between two PVL-MRSA strains present in the unit. Findings All three symptomatic babies and two staff carriers, one of whom was symptomatic, were found to be carrying the South West Pacific (SWP) clone of PVL-MRSA (ST30). One of the staff carriers had recently visited the Philippines and was thought to be the source of the outbreak. Control was established using standard infection control procedures but one baby with relapsing MRSA colonization has required more than 100 days in isolation. Conclusion This is the first reported neonatal outbreak associated with the SWP clone in the UK. Our study highlights the potential risk of further introductions of this organism by healthcare staff or patients epidemiologically linked with the Philippines.

Item Type: Article
Uncontrolled keywords: Meticillin-resistant Staphylococcus aureus; Neonatal infection; Outbreak; Panton–Valentine leucocidin; South West Pacific clone
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Sue Davies
Date Deposited: 27 Mar 2012 13:12
Last Modified: 26 Jun 2014 15:50
Resource URI: http://kar.kent.ac.uk/id/eprint/29203 (The current URI for this page, for reference purposes)
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