Bloemink, Marieke J. and Geeves, M.A. (2011) Shaking the myosin family tree: Biochemical kinetics defines four types of myosin motor. Seminars in Cell & Developmental Biology, 22 (9). pp. 961-967. ISSN 10849521.
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Although all myosin motors follow the same basic cross-bridge cycle, they display a large variety in the rates of transition between different states in the cycle, allowing each myosin to be finely tuned for a specific task. Traditionally, myosins have been classified by sequence analysis into a large number of sub-families (∼35). Here we use a different method to classify the myosin family members which is based on biochemical and mechanical properties. The key properties that define the type of mechanical activity of the motor are duty ratio (defined as the fraction of the time myosin remains attached to actin during each cycle), thermodynamic coupling of actin and nucleotide binding to myosin and the degree of strain-sensitivity of the ADP release step. Based on these properties we propose to classify myosins into four different groups: (I) fast movers, (II) slow/efficient force holders, (III) strain sensors and (IV) gates.
|Additional information:||Processivity; Duty ratio; ADP-release; Strain-sensitivity; Thermodynamic coupling|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences|
|Depositing User:||Sue Davies|
|Date Deposited:||08 Mar 2012 16:17|
|Last Modified:||28 Mar 2012 10:54|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/29008 (The current URI for this page, for reference purposes)|
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