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A novel and versatile computational tool to model translation

Chu, Dominique, Zabet, Nicolae Radu, von der Haar, Tobias (2012) A novel and versatile computational tool to model translation. Bioinformatics, 28 (2). pp. 292-293. ISSN 1367-4803. (doi:10.1093/bioinformatics/btr650) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:28963)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1093/bioinformatics/btr650

Abstract

Motivation: Much is now known about the mechanistic details of gene translation. There are also rapid advances in high-throughput technologies to determine quantitative aspects of the system. As a consequence-realistic and system-wide simulation models of translation are now feasible. Such models are also needed as devices to integrate a large volume of highly fragmented data known about translation.

Software: In this application note, we present a novel, highly efficient software tool to model translation. The tool represents the main aspects of translation. Features include a representation of exhaustible tRNA pools, ribosome–ribosome interactions and differential initiation rates for different mRNA species. The tool is written in Java, and is hence portable and can be parameterized for any organism.

Availability: The model can be obtained from the authors or directly downloaded from the authors' home-page (http://goo.gl/JUWvI).

Item Type: Article
DOI/Identification number: 10.1093/bioinformatics/btr650
Subjects: Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Central Services
Funders: Biotechnology and Biological Sciences Research Council (https://ror.org/00cwqg982)
Depositing User: Dominique Chu
Date Deposited: 24 Feb 2012 13:31 UTC
Last Modified: 12 Jul 2022 10:40 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/28963 (The current URI for this page, for reference purposes)

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