Chu, D. and Zabet, N. and von der Haar, T. (2012) A novel and versatile computational tool to model translation. Bioinformatics, 28 (2). pp. 292-293. ISSN 1367-4803.
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| Official URL http://dx.doi.org/10.1093/bioinformatics/btr650 |
Abstract
Motivation: Much is now known about the mechanistic details of gene translation. There are also rapid advances in high-throughput technologies to determine quantitative aspects of the system. As a consequence-realistic and system-wide simulation models of translation are now feasible. Such models are also needed as devices to integrate a large volume of highly fragmented data known about translation. Software: In this application note, we present a novel, highly efficient software tool to model translation. The tool represents the main aspects of translation. Features include a representation of exhaustible tRNA pools, ribosome–ribosome interactions and differential initiation rates for different mRNA species. The tool is written in Java, and is hence portable and can be parameterized for any organism. Availability: The model can be obtained from the authors or directly downloaded from the authors' home-page (http://goo.gl/JUWvI).
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Biosciences Faculties > Science Technology and Medical Studies > School of Biosciences > Protein Science Group Central Services |
| Depositing User: | Tobias von der Haar |
| Date Deposited: | 24 Feb 2012 13:31 |
| Last Modified: | 28 Feb 2012 11:46 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/28963 (The current URI for this page, for reference purposes) |
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