Rateb, M.E. and Houssen, W.E. and Harrison, W.T.A. and Deng, H. and Okoro, C.K. and Asenjo, J.A. and Andrews, B.A. and Bull, A.T. and Goodfellow, M. and Ebel, R. and Jaspars, M. (2011) Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment. Journal of natural products, 74 (9). pp. 1965-1971. ISSN 1520-6025.
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The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A-C (1-3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5″-dihydrohygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1-3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences|
|Depositing User:||Sue Davies|
|Date Deposited:||03 Nov 2011 11:44|
|Last Modified:||11 Jun 2012 14:52|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/28337 (The current URI for this page, for reference purposes)|
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