Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment

Rateb, Mostafa E. and Houssen, Wael E. and Harrison, William T. A. and Deng, Hai and Okoro, Chinyere K. and Asenjo, Juan A. and Andrews, Barbara A. and Bull, Alan T. and Goodfellow, Michael and Ebel, Rainer and Jaspars, Marcel (2011) Diverse metabolic profiles of a Streptomyces strain isolated from a hyper-arid environment. Journal of Natural Products, 74 (9). pp. 1965-1971. ISSN 1520-6025. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1021/np200470u

Abstract

The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A-C (1-3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5″-dihydrohygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1-3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.

Item Type: Article
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: Sue Davies
Date Deposited: 03 Nov 2011 11:44
Last Modified: 29 Apr 2014 15:22
Resource URI: http://kar.kent.ac.uk/id/eprint/28337 (The current URI for this page, for reference purposes)
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