Cytochrome bd confers nitric oxide resistance to Escherichia coli.

Mason, Maria G and Shepherd, Mark and Nicholls, Peter and Dobbin, Paul S and Dodsworth, Kathryn S and Poole, Robert K and Cooper, Chris E (2009) Cytochrome bd confers nitric oxide resistance to Escherichia coli. Nature chemical biology, 5 (2). pp. 94-6. ISSN 1552-4469. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1038/nchembio.135

Abstract

The aerobic respiratory chain of Escherichia coli has two terminal quinol oxidases: cytochrome bo and cytochrome bd. Cytochrome bd was thought to function solely to facilitate micro-aerobic respiration. However, it has recently been shown to be overexpressed under conditions of nitric oxide (NO) stress; we show here that cytochrome bd is crucial for protecting E. coli cells from NO-induced growth inhibition by virtue of its fast NO dissociation rate.

Item Type: Article
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: Mark Shepherd
Date Deposited: 01 Sep 2011 15:54
Last Modified: 13 Dec 2011 15:24
Resource URI: http://kar.kent.ac.uk/id/eprint/28101 (The current URI for this page, for reference purposes)
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