Mason, Maria G and Shepherd, Mark and Nicholls, Peter and Dobbin, Paul S and Dodsworth, Kathryn S and Poole, Robert K and Cooper, Chris E (2009) Cytochrome bd confers nitric oxide resistance to Escherichia coli. Nature chemical biology, 5 (2). pp. 94-6. ISSN 1552-4469.
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| Official URL http://dx.doi.org/10.1038/nchembio.135 |
Abstract
The aerobic respiratory chain of Escherichia coli has two terminal quinol oxidases: cytochrome bo and cytochrome bd. Cytochrome bd was thought to function solely to facilitate micro-aerobic respiration. However, it has recently been shown to be overexpressed under conditions of nitric oxide (NO) stress; we show here that cytochrome bd is crucial for protecting E. coli cells from NO-induced growth inhibition by virtue of its fast NO dissociation rate.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Biosciences |
| Depositing User: | Mark Shepherd |
| Date Deposited: | 01 Sep 2011 15:54 |
| Last Modified: | 13 Dec 2011 15:24 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/28101 (The current URI for this page, for reference purposes) |
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