Nachtigall, J. and Schneider, K. and Bruntner, C. and Bull, A.T. and Goodfellow, M. and Zinecker, H. and Imhoff, J.F. and Nicholson, G. and Irran, E. and Sussmuth, R.D. and Fiedler, H.P. (2011) Benzoxacystol, a benzoxazine-type enzyme inhibitor from the deep-sea strain Streptomyces sp. NTK 935. The Journal of antibiotics, 64 (6). pp. 453-457. ISSN 0021-8820.
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| Official URL http://dx.doi.org/10.1038/ja.2011.26 |
Abstract
Benzoxacystol, a new 1,4-benzoxazine-type metabolite, was produced by strain NTK 935, a marine member of the Streptomyces griseus 16S rRNA clade, isolated from deep-sea sediment collected from the Canary Basin. The structure of benzoxacystol was determined by mass spectrometry, NMR experiments and X-ray analysis. The compound showed an inhibitory activity against the enzyme glycogen synthase kinase 3β and a weak antiproliferative activity against mouse fibroblast cells.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Biosciences Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group |
| Depositing User: | Sue Davies |
| Date Deposited: | 30 Jun 2011 10:24 |
| Last Modified: | 29 May 2012 09:58 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/27997 (The current URI for this page, for reference purposes) |
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