Benzoxacystol, a benzoxazine-type enzyme inhibitor from the deep-sea strain Streptomyces sp. NTK 935.

Nachtigall, Jonny and Schneider, Kathrin and Bruntner, Christina and Bull, Alan T. and Goodfellow, Michael and Zinecker, Heidi and Imhoff, Johannes F. and Nicholson, Graeme and Irran, Elisabeth and Sussmuth, Roderich D. and Fiedler, Hans-Peter (2011) Benzoxacystol, a benzoxazine-type enzyme inhibitor from the deep-sea strain Streptomyces sp. NTK 935. Journal of Antibiotics, 64 (6). pp. 453-457. ISSN 0021-8820. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1038/ja.2011.26

Abstract

Benzoxacystol, a new 1,4-benzoxazine-type metabolite, was produced by strain NTK 935, a marine member of the Streptomyces griseus 16S rRNA clade, isolated from deep-sea sediment collected from the Canary Basin. The structure of benzoxacystol was determined by mass spectrometry, NMR experiments and X-ray analysis. The compound showed an inhibitory activity against the enzyme glycogen synthase kinase 3β and a weak antiproliferative activity against mouse fibroblast cells.

Item Type: Article
Subjects: Q Science
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Faculties > Science Technology and Medical Studies > School of Biosciences > Biomedical Research Group
Depositing User: Sue Davies
Date Deposited: 30 Jun 2011 10:24
Last Modified: 29 Apr 2014 08:29
Resource URI: http://kar.kent.ac.uk/id/eprint/27997 (The current URI for this page, for reference purposes)
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