Erotokritou-Mulligan, I. and Bassett, E.E. and Kniess, A. and Sonksen, P.H. and Holt, R.I.G. (2007) Validation of the growth hormone (GH)-dependent marker method of detecting GH abuse in sport through the use of independent data sets. Growth Hormone & IGF Research, 17 (5). 416-423 . ISSN 1096-6374 .
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| Official URL http://dx.doi.org/10.1016/j.ghir.2007.04.013 |
Abstract
Context: The detection of exogenously administered growth hormone (GH) poses a formidable challenge but a detection method based on the measurement of two GH-dependent markers, IGF-I and type 3 pro-collagen (P-III-P) has been proposed. The measurement of multiple markers in conjunction with discriminant functions can improve the sensitivity and specificity of detection compared with single marker analysis. Objective: To provide further validation of the GH-dependent marker approach. Design: Analysis of discriminant function scores for GH detection on independent datasets. Setting: Two independent (GH-2000 and Kreischa) double blind, placebo controlled, hGH administration studies. Subjects: Healthy active male volunteers. Intervention: GH-2000 proposed a discriminant function involving IGF-I and P-III- P while the Kreischa function involved IGF-I, P-III-P and IGFBP-3. After adjustment for assay differences the formulae were applied to the other dataset. Outcome measures: Ability to detect GH use in independent datasets using a predefined specificity of approximately 1 in 10000. Results: The GH-2000 formula was able to detect 90% of those receiving GH in the Kreischa study at one or more time points during the study period. This sensitivity was similar to that obtained on the original GH-2000 dataset. The Kreischa formula correctly identified 41% of individuals receiving GH in the GH-2000 study. Conclusions: The study provides further validation that the test proposed by GH-2000 based on IGF-I and P-III-P concentrations can be used to detect subjects receiving exogenous GH.
| Item Type: | Article |
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| Uncontrolled keywords: | growth hormone; sport; abuse; discriminant function; markers |
| Subjects: | Q Science > QA Mathematics (inc Computing science) Q Science > QH Natural history > QH301 Biology |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Mathematics Statistics and Actuarial Science > Statistics |
| Depositing User: | Louise Dorman |
| Date Deposited: | 24 Apr 2008 08:22 |
| Last Modified: | 14 Jan 2010 14:08 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/2766 (The current URI for this page, for reference purposes) |
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