Silane-based hybrids for biomedical applications

Kros, Alexander and Jansen, John A. and Holder, Simon J. and Nolte, Roeland J.M. and Sommerdijk, Nico A. J. M. (2002) Silane-based hybrids for biomedical applications. Journal of Adhesion Science and Technology, 16 (2). pp. 143-155. ISSN 0169-4243. (The full text of this publication is not available from this repository)

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Abstract

In this paper, the preparation of different hybrid silane materials is presented and their possible use in biomedical applications is discussed. The first example describes the development of biocompatible coatings based on sol-gel silicates, which can be used as a protective coating for implantable glucose sensors. Blending the silica with different organic polymers modified the properties of the resulting sot-gel materials. Their biocompatibility, both in vivo and in vitro, and their applications on biosensors were investigated. In the second example, an amphiphilic block copolymer comprising hydrophilic poly(ethylene oxide) blocks and hydrophobic poly(methylphenylsilane) segments is presented. In aqueous medium, this polymer forms vesicles in which a fluorescent dye is encapsulated. It was demonstrated that the vesicle aggregates could be broken up using UV irradiation. indicating that these vesicles were potentially interesting as controlled release systems. Monolayer studies confirmed that after photolytic cleavage of the poly(methylphenylsilane) segments, no organized structures were formed from the remaining material.

Item Type: Article
Additional information: 39 VSP BV
Uncontrolled keywords: sol-gel; silica; biocompatibility; biomedical; amperometric biosensor; polysilane; self-assembly; copolymers COIL BLOCK-COPOLYMERS; SOL-GEL PROCESS; GLUCOSE SENSORS; ENCAPSULATION; TISSUE
Subjects: Q Science > QD Chemistry
Divisions: Faculties > Science Technology and Medical Studies > School of Physical Sciences > Functional Materials Group
Faculties > Science Technology and Medical Studies > School of Physical Sciences
Depositing User: Simon Holder
Date Deposited: 29 Aug 2008 11:03
Last Modified: 22 May 2014 10:28
Resource URI: http://kar.kent.ac.uk/id/eprint/2557 (The current URI for this page, for reference purposes)
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