Jouyban, A. and Shokri, J. and Barzegar-Jalali, M. and Hassan-Zadeh, D. and Acree, W.E. and Ghafourian, T. and Nokhodchi, A. (2009) Solubility of Chlordiazepoxide, Diazepam, and Lorazepam in Ethanol + Water Mixtures at 303.2 K. Journal of Chemical Engineering Data, 54 (7). pp. 2142-2145. ISSN 0021-9568.
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| Official URL http://dx.doi.org/10.1021/je900200k |
Abstract
Experimental solubilities of three benzodiazepines (chlordiazepoxide, diazepam, and lorazepam) in ethanol + water mixtures at 303.2 K are reported. The solubility of drugs was increased with the addition of ethanol and reached the maximum value of a volume fraction of 90 % of ethanol. The Jouyban−Acree model was used to fit the experimental data, and the solubilities were reproduced using previously trained version of the Jouyban−Acree model and the solubility data in monosolvents in which the overall mean relative deviations (OMRDs) of the models were 8.6 %, 21.9 % and 19.3 %, respectively, for the fitted model, the trained version for ethanol + water mixtures and generally trained version for various organic solvents + water mixtures.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Faculties > Science Technology and Medical Studies > Medway School of Pharmacy |
| Depositing User: | Taravat Ghafourian |
| Date Deposited: | 26 Oct 2010 14:50 |
| Last Modified: | 18 Jul 2012 08:33 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/25031 (The current URI for this page, for reference purposes) |
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