Chu, Dominique (2008) Modes of evolution in a parasite�host interaction: Dis-entangling factors determining the evolution of regulated fimbriation in E. coli. Biosystems, 95 (1). pp. 67-74. ISSN 0303-2647. (Full text available)
Escherichia coli expresses type-I fimbriae; these are protrusions from the outer cell wall and have been identified as a virulence factor. They are also expressed by commensal strains of E. coli although (at any one time) only by a small proportion of the population. The orthodox interpretation of this is that fimbriation is regulated so as (i) to trigger a host-based release of nutrients in the form of inflammation signals by slightly activating host defenses and (ii) while avoiding a full scale inflammatory response. This article presents a number of computer simulations of the evolution of fimbriae to scrutinize the evolutionary plausibility of this orthodox view. It turns out that these simulations suggest a revised interpretation of the fimbriae mediated parasitehost interaction. Rather than being a passive victim the host is actively providing a niche that evolutionary favors less virulent parasites. The article closes with a number of testable predictions of this model.
|Subjects:||Q Science > QA Mathematics (inc Computing science) > QA 76 Software, computer programming,|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Computing > Applied and Interdisciplinary Informatics Group|
|Depositing User:||Dominique Chu|
|Date Deposited:||29 Mar 2010 12:11|
|Last Modified:||04 Dec 2013 09:50|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/24035 (The current URI for this page, for reference purposes)|