Skip to main content
Kent Academic Repository

02-P015 Dcamsap (ssp4) is a member of a family of membrane-skeleton proteins essential for the life of animals

Coates, Liz, Baines, Anthony J., Allen, Marcus J. (2009) 02-P015 Dcamsap (ssp4) is a member of a family of membrane-skeleton proteins essential for the life of animals. Mechanisms of Development, 126 Su . S64-S64. ISSN 0925-4773. (doi:10.1016/j.mod.2009.06.045) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:22848)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1016/j.mod.2009.06.045

Abstract

The CAMSAP1 gene in vertebrates is a spectrin associated protein that is regulated by Ca2+/calmodulin. It is a member of a family of protein in animals, of unknown function, that contain a calponin homology (CH) domain and a conserved C-terminal DUF1781 domain. Invertebrates have single CAMSAP genes and vertebrates generally have three. The Drosophila homologue of CAMSAP1 is Dcamsap (ssp4). Transposon insertion mutations in Dcamsap are lethal. Fly embryos die before hatching with defects in head involution.

We have generated an antibody to the C-terminus of Dcamsap and investigated the expression of the gene using western blotting and by immunocytochemistry to whole-mount embryos. Expression is elevated in discrete cells that may be undergoing apoptosis. Analysis of both the insertion mutations and also dsRNAi knockdown of Dcamsap in the eye indicate that Dcamsap is required for regulation of cell number during development.

Item Type: Article
DOI/Identification number: 10.1016/j.mod.2009.06.045
Additional information: 16th International Society of Developmental Biologists Congress 2009
Subjects: Q Science > QP Physiology (Living systems)
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Marcus J Allen
Date Deposited: 25 Sep 2009 11:31 UTC
Last Modified: 16 Nov 2021 10:01 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/22848 (The current URI for this page, for reference purposes)

University of Kent Author Information

Baines, Anthony J..

Creator's ORCID:
CReDIT Contributor Roles:

Allen, Marcus J..

Creator's ORCID:
CReDIT Contributor Roles:
  • Depositors only (login required):

Total unique views for this document in KAR since July 2020. For more details click on the image.