Lellouche, J.P. and Senthil, G. and Joseph, A. and Buzhansky, L. and Bruce, I.J. and Bauminger, E.R. and Schlesinger, J. (2005) Magnetically responsive carboxylated magnetite-polydipyrrole/polydicarbazole nanocomposites of core-shell morphology. Preparation, characterization, and use in DNA hybridization. Journal of the American Chemical Society, 127 (34). pp. 11988-12006. ISSN 0002-7863 .
| The full text of this publication is not available from this repository. (Contact us about this Publication) | |
| Official URL http://dx.doi.org/10.1021/ja050285l |
Abstract
Novel bis-heterocyclic mono- and dicarboxylated dipyrrole and dicarbazole monomers have been synthesized in a modular manner. Their oxidative polymerization around magnetite nanosized particles has been investigated and optimized toward new magnetic magnetite-polydipyrrole/polydicarbazole nanocomposites (NCs) of a core-shell morphology. These NCs were thoroughly characterized by FT-IR, TGA (Thermal Gravimetric Analysis), low- and high-resolution TEM/HR-TEM microscopies, and Mossbauer spectroscopy along with magnetization studies. Exploiting the versatile COOH chemistry (activation by water-soluble diimides) introduced by the polymeric shell, DNA hybridization experiments have been conducted onto NC surfaces using an efficient blue-colored HRP-based enzymatic screening biological system. Highly parallel NC-supported DNA hybridization experimentations revealed that these NCs presented an interesting potential for DNA-based diagnostic applications.
| Item Type: | Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Biosciences |
| Depositing User: | Suzanne Duffy |
| Date Deposited: | 11 Sep 2009 14:39 |
| Last Modified: | 11 Sep 2009 14:39 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/22818 (The current URI for this page, for reference purposes) |
- Depositors only (login required):
