One for all? A viral protein supplants the mRNA cap-binding complex

von der Haar, Tobias (2009) One for all? A viral protein supplants the mRNA cap-binding complex. Embo Journal, 28 (1). pp. 6-7. ISSN 0261-4189. (Full text available)

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http://dx.doi.org/10.1038/emboj.2008.251

Abstract

Modulation of the host cell’s translational machinery is a crucial part of viral infection strategies.Well-characterised mechanisms that aid viruses in manipulating translational activity include, for example, internal ribosomal entry sites, which allow viral RNA translation in the absence of some or many of the canonical host translation factors. New research shows that the nucleocapsid protein from a species of Hantavirus can replace several host cell translation factors in in vitro translation reactions, suggesting that hantaviruses may have evolved a novel strategy for modulating host cell translation in the form of a multifunctional translation factor.

Item Type: Article
Projects: [121] 075438
Subjects: Q Science > QP Physiology (Living systems) > QP506 Molecular biology
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences > Protein Science Group
Depositing User: Tobias von der Haar
Date Deposited: 27 Oct 2009 16:01
Last Modified: 15 Apr 2014 08:39
Resource URI: http://kar.kent.ac.uk/id/eprint/22644 (The current URI for this page, for reference purposes)
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