von der Haar, T. (2009) One for all? A viral protein supplants the mRNA cap-binding complex. The EMBO Journal, 28 (1). pp. 6-7. ISSN 0261-4189/09. (Full text available)
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Modulation of the host cell’s translational machinery is a crucial part of viral infection strategies.Well-characterised mechanisms that aid viruses in manipulating translational activity include, for example, internal ribosomal entry sites, which allow viral RNA translation in the absence of some or many of the canonical host translation factors. New research shows that the nucleocapsid protein from a species of Hantavirus can replace several host cell translation factors in in vitro translation reactions, suggesting that hantaviruses may have evolved a novel strategy for modulating host cell translation in the form of a multifunctional translation factor.
|Subjects:||Q Science > QP Physiology (Living systems) > QP506 Molecular biology|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences > Protein Science Group|
|Depositing User:||Tobias von der Haar|
|Date Deposited:||27 Oct 2009 16:01|
|Last Modified:||06 Sep 2011 04:23|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/22644 (The current URI for this page, for reference purposes)|