The actin cytoskeleton in ageing and apoptosis.

Gourlay, Campbell W. and Ayscough, K.R. (2005) The actin cytoskeleton in ageing and apoptosis. In: 3rd International Meeting on Yeast Apoptosis, Austria, Aug, 2004, Salzburg, . (The full text of this publication is not available from this repository)

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Abstract

Regulated cell death, or apoptosis, has evolved to fulfil a myriad of functions amongst multicellular organisms. It is now apparent that programmed cell death occurs in unicellular organisms such as yeast. In yeast, as in higher eukaryotes, the actin cytoskeleton is an essential component of a number of cellular activities, and many of the regulatory proteins involved are highly conserved. Recent evidence from diverse eukaryotic systems suggests that the actin cytoskeleton has a role in regulating apoptosis via interactions with the mitochondria. This interaction also appears to have a significant impact on the management of oxidative stress and so cellular ageing. In this mini-review we summarise some of the work, which suggests that actin is a key regulator of apoptosis and ageing in eukaryotic cells.

Item Type: Conference or workshop item (Paper)
Uncontrolled keywords: yeast; ROS; mitochondria; senescence; programmed cell death; stress
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: Campbell Gourlay
Date Deposited: 29 Sep 2009 16:03
Last Modified: 09 Aug 2013 08:06
Resource URI: http://kar.kent.ac.uk/id/eprint/22642 (The current URI for this page, for reference purposes)
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