Hovey, A. and Bebbington, C.R and Jenkins, N. (1994) Control of Growth and Recombinant Protein-Synthesis by Heat-Shock - in a Mutant Mmmalian-Cell line. Biotechnology Letters, 16 (3). pp. 215-220. ISSN 0141-5492.
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The effect of heat-shock on cell growth and the induction of recombinant protein synthesis by a temperature-sensitive (ts) Chinese hamster ovary (CHO) cell line was investigated. An optimal regime of successive 2 hour heat-shocks (42 degrees C) over 72 hours was found to simultaneously arrest cell growth and induce the synthesis of recombinant protein. The enhanced induction achieved from growth arrested cells may find application in the production of cytotoxic proteins.
|Subjects:||Q Science > QP Physiology (Living systems) > QP517 Biochemistry|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences|
|Depositing User:||P. Ogbuji|
|Date Deposited:||25 Jun 2009 13:19|
|Last Modified:||25 Jun 2009 13:19|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/20259 (The current URI for this page, for reference purposes)|
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