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Receptors for ADP on Human Blood-Platelets

Hourani, S.M.O., Hall, D.A. (1994) Receptors for ADP on Human Blood-Platelets. Trends in Pharmacological Sciences, 15 (4). pp. 103-108. ISSN 0165-6147. (doi:10.1016/0165-6147(94)90045-0) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:20257)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1016/0165-6147(94)90045-0

Abstract

It is well established that ADP causes aggregation of human blood platelets, and indeed it was the first aggregating agent to be studied, but the ways in which platelets respond to ADP are still relatively obscure. Although it is apparent that increases in intracellular Ca2+ concentrations are of major importance in activating platelets, it is not clearly understood how ADP causes these increases and what other signal transduction mechanisms it uses. It is not even clear whether ADP causes its effects by interacting with only one receptor, or whether multiple receptors for ADP exist on platelets. In this review, Susanna Hourani and David Hall examine some of the conflicting evidence in this field, and draw some tentative conclusions about the number and nature of receptors for ADP on human platelets.

Item Type: Article
DOI/Identification number: 10.1016/0165-6147(94)90045-0
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Divisions > Division for the Study of Law, Society and Social Justice > School of Social Policy, Sociology and Social Research
Depositing User: P. Ogbuji
Date Deposited: 25 Jun 2009 13:36 UTC
Last Modified: 16 Nov 2021 09:58 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/20257 (The current URI for this page, for reference purposes)

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