Hourani, S.M.O. and Hall, D.A. (1994) Receptors for ADP on Human Blood-Platelets. Trends in Pharmacological Sciences, 15 (4). pp. 103-108. ISSN 0165-6147.
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It is well established that ADP causes aggregation of human blood platelets, and indeed it was the first aggregating agent to be studied, but the ways in which platelets respond to ADP are still relatively obscure. Although it is apparent that increases in intracellular Ca2+ concentrations are of major importance in activating platelets, it is not clearly understood how ADP causes these increases and what other signal transduction mechanisms it uses. It is not even clear whether ADP causes its effects by interacting with only one receptor, or whether multiple receptors for ADP exist on platelets. In this review, Susanna Hourani and David Hall examine some of the conflicting evidence in this field, and draw some tentative conclusions about the number and nature of receptors for ADP on human platelets.
|Subjects:||R Medicine > RM Therapeutics. Pharmacology|
|Divisions:||Faculties > Science Technology and Medical Studies > Kent Institute of Medicine and Health Sciences (KIMHS)|
|Depositing User:||P. Ogbuji|
|Date Deposited:||25 Jun 2009 13:36|
|Last Modified:||13 Jun 2012 08:34|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/20257 (The current URI for this page, for reference purposes)|
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