Puncher, M.R.B. and Blower, P.J. (1994) Radionuclide targeting and dosimetry at the microscopic level - the role of microautoradiography. European Journal of Nuclear Medicine, 21 (12). pp. 1347-1365. ISSN 0340-6997.
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The understanding of localisation mechanisms and microdosimetry of diagnostic and therapeutic radiopharmaceuticals depends on knowledge of their biodistribution at the microscopic level (cellular and subcellular) in the target tissues. Various methods have been advanced for obtaining information about this microdistribution: subcellular fractionation, secondary ion mass spectrometry imaging, microprobe elemental analysis in the electron microscope, and microautoradiography. This review compares these approaches, and discusses in detail the methodology of microautoradiography (the most generally useful approach) with imaging and therapy radionuclides, Literature examples of applications of microautoradiography in nuclear medicine are reviewed, and the future potential contribution of the techniques is assessed.
|Uncontrolled keywords:||microautoradiography; radionuclides|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences|
|Depositing User:||O.O. Odanye|
|Date Deposited:||10 Jun 2009 07:56|
|Last Modified:||09 May 2012 09:08|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/19964 (The current URI for this page, for reference purposes)|
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