The in situ size of the dopamine transporter is a tetramer as estimated by radiation inactivation

Milner, Helen E. and Beliveau, Richard and Jarvis, Simon M. (1994) The in situ size of the dopamine transporter is a tetramer as estimated by radiation inactivation. Biochimica Et Biophysica Acta-Biomembranes, 1190 (1). pp. 185-187. ISSN 0005-2736. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1016/0005-2736(94)90051-5

Abstract

Radiation inactivation analysis of the mazindol-sensitive binding of the dopamine transporter inhibitor, [H-3]GBR-12935 to canine striatal membranes yielded a radiation inactivation target size of 278 +/- 16 kDa. This result, in conjunction with other findings in the literature demonstrating that the molecular mass of the dopamine transporter is similar to 70 kDa, suggests that the native form of the dopamine carrier in the neuronal membranes is a tetrameric assembly of identical 70 kDa subunits.

Item Type: Article
Uncontrolled keywords: dopamine transporter; radiation inactivation; gbr-12935; (canine brain membrane)
Subjects: Q Science > QP Physiology (Living systems) > QP517 Biochemistry
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: O.O. Odanye
Date Deposited: 06 Jul 2009 19:31
Last Modified: 20 Jun 2014 14:03
Resource URI: http://kar.kent.ac.uk/id/eprint/19913 (The current URI for this page, for reference purposes)
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