Lenn, M.J. and Knowles, C.J. (1994) Production of optically active lactones using cycloalkanone oxygenases. Enzyme and Microbial Technology, 16 (11). pp. 964-969. ISSN 0141-0229.
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Abstract
The oxidation of a number of bicyclic [n.2.0] ketones has been investigated using a novel bacterial isolate, Pseudomonas putida AS1. The organism was shown to promote similar Baeyer-Villiger type oxidations to the well-characterized organism, Acinetobacter sp. NCIMB 9871. A number of trends were noted with respect to the effect of different substitutions on the substrate on the regio- and stereoselectivity of the whole-cell-catalyzed reactions. These observations are of importance in defining the steric requirements for selectivity in cyclohexanone monooxygenase-catalyzed reactions. Pseudomonas putida AS1 is proposed as an alternative biocatalyst to the pathogenic Acinetobacter species.
| Item Type: | Article |
|---|---|
| Uncontrolled keywords: | baeyer-villiger oxidation; biotransformation; cyclohexanone monooxygenase; bicyclic lactones; enantioselectivity |
| Subjects: | Q Science > QR Microbiology |
| Divisions: | Faculties > Science Technology and Medical Studies > School of Biosciences |
| Depositing User: | O.O. Odanye |
| Date Deposited: | 12 Jul 2009 17:37 |
| Last Modified: | 30 Jul 2012 10:56 |
| Resource URI: | http://kar.kent.ac.uk/id/eprint/19851 (The current URI for this page, for reference purposes) |
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