Lenn, M.J. and Knowles, C.J. (1994) Production of optically active lactones using cycloalkanone oxygenases. Enzyme and Microbial Technology, 16 (11). pp. 964-969. ISSN 0141-0229.
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The oxidation of a number of bicyclic [n.2.0] ketones has been investigated using a novel bacterial isolate, Pseudomonas putida AS1. The organism was shown to promote similar Baeyer-Villiger type oxidations to the well-characterized organism, Acinetobacter sp. NCIMB 9871. A number of trends were noted with respect to the effect of different substitutions on the substrate on the regio- and stereoselectivity of the whole-cell-catalyzed reactions. These observations are of importance in defining the steric requirements for selectivity in cyclohexanone monooxygenase-catalyzed reactions. Pseudomonas putida AS1 is proposed as an alternative biocatalyst to the pathogenic Acinetobacter species.
|Uncontrolled keywords:||baeyer-villiger oxidation; biotransformation; cyclohexanone monooxygenase; bicyclic lactones; enantioselectivity|
|Subjects:||Q Science > QR Microbiology|
|Divisions:||Faculties > Science Technology and Medical Studies > School of Biosciences|
|Depositing User:||O.O. Odanye|
|Date Deposited:||12 Jul 2009 17:37|
|Last Modified:||30 Jul 2012 10:56|
|Resource URI:||http://kar.kent.ac.uk/id/eprint/19851 (The current URI for this page, for reference purposes)|
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