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Production of optically active lactones using cycloalkanone oxygenases

Lenn, Michael J., Knowles, Christopher J. (1994) Production of optically active lactones using cycloalkanone oxygenases. Enzyme and Microbial Technology, 16 (11). pp. 964-969. ISSN 0141-0229. (doi:10.1016/0141-0229(94)90005-1) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:19851)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL:
http://dx.doi.org/10.1016/0141-0229(94)90005-1

Abstract

The oxidation of a number of bicyclic [n.2.0] ketones has been investigated using a novel bacterial isolate, Pseudomonas putida AS1. The organism was shown to promote similar Baeyer-Villiger type oxidations to the well-characterized organism, Acinetobacter sp. NCIMB 9871. A number of trends were noted with respect to the effect of different substitutions on the substrate on the regio- and stereoselectivity of the whole-cell-catalyzed reactions. These observations are of importance in defining the steric requirements for selectivity in cyclohexanone monooxygenase-catalyzed reactions. Pseudomonas putida AS1 is proposed as an alternative biocatalyst to the pathogenic Acinetobacter species.

Item Type: Article
DOI/Identification number: 10.1016/0141-0229(94)90005-1
Uncontrolled keywords: baeyer-villiger oxidation; biotransformation; cyclohexanone monooxygenase; bicyclic lactones; enantioselectivity
Subjects: Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: O.O. Odanye
Date Deposited: 12 Jul 2009 17:37 UTC
Last Modified: 16 Nov 2021 09:58 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/19851 (The current URI for this page, for reference purposes)

University of Kent Author Information

Knowles, Christopher J..

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