Differencial Synthesis of Glyceraldehyde-3-Phosphate Dehydrogenase Polypeptide in Stressed Yeast-Cells

Boucherie, Helian and Bataille, Nelly and Fitch, Ian T. and Perrot, Michel and Tuite, Mick F. (1995) Differencial Synthesis of Glyceraldehyde-3-Phosphate Dehydrogenase Polypeptide in Stressed Yeast-Cells. FEMS Microbiology Letters, 125 (2-3). pp. 127-133. ISSN 03781097. (The full text of this publication is not available from this repository)

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Official URL
http://dx.doi.org/10.1016/0378-1097(94)00484-9

Abstract

Three unlinked genes, TDH1, TDH2 and TDH3, encode the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (triose-phosphate dehydrogenase; TDH) in the yeast Saccharomyces cervisiae. We demonstrate that the synthesis of the three encoded TDH polypeptides (TDHa, TDHb and TDHc, respectively) is not co-ordinately regulated and that TDHa is only synthesised as cells enter stationary phase, due to glucose starvation, or in heat-shocked cells. Furthermore, the synthesis of TDHb, but not TDHc, is strongly repressed by a heat shock. Hence, the TDHa enzyme may play a cellular role, distinct from glycolysis, that is required by stressed cells.

Item Type: Article
Uncontrolled keywords: SACCHAROMYCES CEREVISIAE; TRIOSE PHOSPHATE DEHYDROGENASE (GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE) STRESS RESPONSE; HEAT SHOCK
Subjects: Q Science > QP Physiology (Living systems) > QP517 Biochemistry
Divisions: Faculties > Science Technology and Medical Studies > School of Biosciences
Depositing User: P. Ogbuji
Date Deposited: 08 Jun 2009 09:05
Last Modified: 24 Apr 2014 08:10
Resource URI: http://kar.kent.ac.uk/id/eprint/19713 (The current URI for this page, for reference purposes)
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